Quincy University is a constituent member of the National Catholic Education Association of American Colleges, and is affiliated with the Catholic University of America.

Quincy University is also a member of the American Council on Education, Council of Independent Colleges, Association of Franciscan Colleges and Universities, the Associated Colleges of Illinois, the Federation of Independent Illinois Colleges and Universities, Association for Supervision and Curriculum Development, Illinois Association of Colleges for Teacher Education, Illinois Association of Teacher Educators, Illinois Association for Teacher Education in Private Colleges, and the Council for Exceptional Children.

All Quincy University teacher licensure programs, administrative licensure programs, and school counselor licensure programs are fully accredited by the Illinois State Board of Education.

The University is approved by the State Approving Agency for educational assistance benefits to veterans and veterans' dependents and by the Immigration and Naturalization Service of the U.S. Department of Justice.